De Luca, Chiara, Gugliandolo, Agnese, Calabrò, Carlo et al. · Mediators of inflammation · 2015 · DOI
This study looked at genetic variations in genes that control nitric oxide (a chemical messenger in the body) in people with ME/CFS, fibromyalgia, and chemical sensitivities. Researchers found that certain genetic patterns were more common in these patient groups and were associated with higher levels of oxidative stress markers, suggesting these genetic differences might play a role in these overlapping conditions.
ME/CFS shares pathological features with fibromyalgia and chemical sensitivities (oxidative stress, inflammation), and this study identifies specific genetic markers that may help explain the biological basis of these interconnected conditions. Understanding genetic susceptibility to nitric oxide dysregulation could guide future therapeutic interventions targeting this pathway in ME/CFS.
This study does not prove that these genetic polymorphisms cause ME/CFS or related conditions—only that they are associated with them. The polymorphisms may be markers of underlying vulnerability rather than direct causative factors, and association in one population may not replicate universally. The study does not establish whether nitrite/nitrate elevation is beneficial or harmful in these conditions.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
De Luca, Chiara, Gugliandolo, Agnese, Calabrò, Carlo, Currò, Monica, Ientile, Riccardo, Raskovic, Desanka, et al. (2015). Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances.. Mediators of inflammation. https://doi.org/10.1155/2015/245308
BibTeX
@article{mecfsatlas-de-luca-2015-role-polymorphisms,
author = {De Luca, Chiara and Gugliandolo, Agnese and Calabrò, Carlo and Currò, Monica and Ientile, Riccardo and Raskovic, Desanka and Korkina, Ludmila and Caccamo, Daniela},
title = {Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances.},
journal = {Mediators of inflammation},
year = {2015},
doi = {10.1155/2015/245308},
note = {PubMed: 25878398},
url = {https://www.mecfsatlas.com/evidence/de-luca-2015-role-polymorphisms},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/de-luca-2015-role-polymorphisms
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