Esipov, A V, Ivolgin, A F, Khritinin, D F et al. · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2019 · DOI
This study tested whether a medication called cytoflavin, which helps cells produce energy, could help 100 patients with fatigue and sleep problems. Patients received cytoflavin as an infusion, either alone or combined with melatonin or another sleep medication. By day 14, 97% of patients reported significant improvement in fatigue and sleep quality.
ME/CFS is characterized by post-exertional malaise, fatigue, and sleep dysfunction similar to asthenic syndrome. This study explores whether metabolic support via cytoflavin—a mitochondrial energizer with antioxidant properties—might ameliorate core symptoms, potentially informing novel approaches to managing ME/CFS-related fatigue and insomnia.
This study does not prove cytoflavin is effective for ME/CFS specifically, as it studied heterogeneous asthenic syndromes of unclear etiology. The absence of a placebo control makes it impossible to distinguish true drug efficacy from placebo response or natural recovery. The high response rate (97%) warrants skepticism given the lack of blinding and use of subjective outcome measures.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Esipov, A V, Ivolgin, A F, Khritinin, D F, Katenko, S V, Kazakov, S P, Karakozov, A G, et al. (2019). [Clinical efficacy of neurometabolic therapy of dissomical disorders in asthenic syndrome].. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. https://doi.org/10.17116/jnevro201911909146
BibTeX
@article{mecfsatlas-esipov-2019-clinical-efficacy,
author = {Esipov, A V and Ivolgin, A F and Khritinin, D F and Katenko, S V and Kazakov, S P and Karakozov, A G and Kalyagin, I E and Levchenko, O B and Molodova, A I},
title = {[Clinical efficacy of neurometabolic therapy of dissomical disorders in asthenic syndrome].},
journal = {Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova},
year = {2019},
doi = {10.17116/jnevro201911909146},
note = {PubMed: 31626218},
url = {https://www.mecfsatlas.com/evidence/esipov-2019-clinical-efficacy},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/esipov-2019-clinical-efficacy
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