Fasih, T, Pickin, M, Cuschieri, R J · International journal of clinical practice · 2003
Doctors sometimes see patients complaining of leg pain that resembles poor circulation (claudication), but the pain isn't actually caused by blood vessel problems. This study looked at over 1,000 patients with suspected circulation problems and found that 33 had other causes for their symptoms, including spine problems, nerve damage, or other conditions. One patient was diagnosed with chronic fatigue syndrome (ME/CFS). The study highlights that doctors need to correctly identify the real cause of symptoms before recommending treatments.
This study demonstrates that ME/CFS can present with claudication-like leg symptoms that may be mistaken for vascular disease, highlighting the importance of differential diagnosis. For ME/CFS patients, the finding underscores that fatigue-related symptoms may manifest in ways that resemble other medical conditions, and proper evaluation is essential to avoid unnecessary or harmful interventions.
This case report does not establish the prevalence of ME/CFS among claudication patients, nor does it characterize the symptom profile of ME/CFS-related claudication-like symptoms. The single ME/CFS case cannot define relationships between ME/CFS and leg claudication symptoms, and no pathophysiological mechanism is explored.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Fasih, T, Pickin, M, & Cuschieri, R J (2003). Non-vascular claudication: a clinical conundrum.. International journal of clinical practice. https://pubmed.ncbi.nlm.nih.gov/12661788/
BibTeX
@article{mecfsatlas-fasih-2003-non-vascular,
author = {Fasih, T and Pickin, M and Cuschieri, R J},
title = {Non-vascular claudication: a clinical conundrum.},
journal = {International journal of clinical practice},
year = {2003},
note = {PubMed: 12661788},
url = {https://www.mecfsatlas.com/evidence/fasih-2003-non-vascular},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/fasih-2003-non-vascular
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