Froghi, Saied, Grant, Charlotte R, Tandon, Radhika et al. · Clinical reviews in allergy & immunology · 2021 · DOI
This review examines how calcium moves into cells through special channels called TRP channels, and how this process affects the immune system. The authors explain that TRP channels play important roles in helping immune cells fight infections and respond to threats. They discuss evidence that problems with these calcium channels may be involved in several diseases, including ME/CFS.
This review identifies TRP channels as potentially important regulators of immune dysfunction in ME/CFS, providing a molecular framework for understanding immune dysregulation in the disease. Understanding calcium signaling abnormalities could eventually lead to new diagnostic biomarkers or therapeutic targets specific to ME/CFS pathophysiology.
As a narrative review, this study does not provide direct experimental evidence that TRP channel dysfunction causes ME/CFS—it identifies associations and theoretical mechanisms. The review does not establish which specific TRP channels are dysfunctional in ME/CFS patients or prove causation rather than correlation with disease. The abstract does not describe how the authors selected or critically appraised included studies.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Froghi, Saied, Grant, Charlotte R, Tandon, Radhika, Quaglia, Alberto, Davidson, Brian, & Fuller, Barry (2021). New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice.. Clinical reviews in allergy & immunology. https://doi.org/10.1007/s12016-020-08824-3
BibTeX
@article{mecfsatlas-froghi-2021-new-insights,
author = {Froghi, Saied and Grant, Charlotte R and Tandon, Radhika and Quaglia, Alberto and Davidson, Brian and Fuller, Barry},
title = {New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice.},
journal = {Clinical reviews in allergy & immunology},
year = {2021},
doi = {10.1007/s12016-020-08824-3},
note = {PubMed: 33405100},
url = {https://www.mecfsatlas.com/evidence/froghi-2021-new-insights},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/froghi-2021-new-insights
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