Fukuda, Sanae, Horiguchi, Mieko, Yamaguti, Kouzi et al. · Life sciences · 2013 · DOI
This study looked at whether specific genetic variations in two genes (GCH and TH) that help make important brain chemicals were linked to ME/CFS. Researchers compared DNA from ME/CFS patients and healthy controls and gave patients personality and fatigue questionnaires. They found that while these genetic variations weren't directly connected to developing ME/CFS, certain variations were associated with specific personality traits—like how perfectionist or cautious someone tends to be.
Understanding the genetic basis of personality traits in ME/CFS patients may help explain why some individuals develop characteristic psychological features like perfectionism and heightened anxiety. This research bridges neurobiology and psychology in ME/CFS, potentially opening new avenues for understanding both disease mechanisms and tailoring supportive interventions.
This study does not prove that these genetic variations cause ME/CFS or directly determine personality—it only shows associations in already-affected patients. The cross-sectional design cannot establish causality, and findings about personality traits do not mean that psychological factors cause the disease. Larger longitudinal studies would be needed to determine whether these genetic variants actually influence disease development.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Fukuda, Sanae, Horiguchi, Mieko, Yamaguti, Kouzi, Nakatomi, Yasuhito, Kuratsune, Hirohiko, Ichinose, Hiroshi, et al. (2013). Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients.. Life sciences. https://doi.org/10.1016/j.lfs.2012.11.016
BibTeX
@article{mecfsatlas-fukuda-2013-association-monoamine,
author = {Fukuda, Sanae and Horiguchi, Mieko and Yamaguti, Kouzi and Nakatomi, Yasuhito and Kuratsune, Hirohiko and Ichinose, Hiroshi and Watanabe, Yasuyoshi},
title = {Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients.},
journal = {Life sciences},
year = {2013},
doi = {10.1016/j.lfs.2012.11.016},
note = {PubMed: 23246742},
url = {https://www.mecfsatlas.com/evidence/fukuda-2013-association-monoamine},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/fukuda-2013-association-monoamine
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