Fukuda, Sanae, Nojima, Junzo, Motoki, Yukari et al. · Biological psychology · 2016 · DOI
This study looked at whether certain markers of cellular damage from harmful molecules (oxidative stress) and the body's ability to repair that damage (antioxidant capacity) could be used to identify ME/CFS patients and measure their fatigue levels. Researchers compared these markers in ME/CFS patients at rest versus healthy people during and after exercise, finding that ME/CFS patients had a different pattern of these markers compared to healthy controls.
Finding reliable biomarkers to identify ME/CFS and distinguish it from normal fatigue is a major clinical need, as ME/CFS diagnosis currently relies entirely on symptom criteria. If validated, oxidative stress markers could provide objective laboratory evidence to support diagnosis and track disease severity or treatment response.
This study does not prove that oxidative stress causes ME/CFS, only that it is associated with the condition at rest. The cross-sectional design cannot establish whether oxidative stress is a primary driver of ME/CFS pathology, a consequence of the disease, or a marker of underlying dysfunction. The clinical utility and reproducibility of these biomarkers across different laboratories and populations remain unproven.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Fukuda, Sanae, Nojima, Junzo, Motoki, Yukari, Yamaguti, Kouzi, Nakatomi, Yasuhito, Okawa, Naoko, et al. (2016). A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity.. Biological psychology. https://doi.org/10.1016/j.biopsycho.2016.05.005
BibTeX
@article{mecfsatlas-fukuda-2016-potential-biomarker,
author = {Fukuda, Sanae and Nojima, Junzo and Motoki, Yukari and Yamaguti, Kouzi and Nakatomi, Yasuhito and Okawa, Naoko and Fujiwara, Kazumi and Watanabe, Yasuyoshi and Kuratsune, Hirohiko},
title = {A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity.},
journal = {Biological psychology},
year = {2016},
doi = {10.1016/j.biopsycho.2016.05.005},
note = {PubMed: 27224647},
url = {https://www.mecfsatlas.com/evidence/fukuda-2016-potential-biomarker},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/fukuda-2016-potential-biomarker
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