Gascón, J, Marcos, T, Vidal, J et al. · Journal of travel medicine · 1995 · DOI
This study looked at whether two common viruses—cytomegalovirus (CMV) and Epstein-Barr virus (EBV)—might be responsible for causing ME/CFS in people who had traveled to tropical regions. The researchers observed a group of travelers and tracked whether those infected with these viruses developed chronic fatigue symptoms similar to ME/CFS.
This research explores potential viral triggers for ME/CFS, which remains relevant since viral infections are hypothesized to precipitate ME/CFS in some patients. Understanding whether specific pathogens encountered in tropical travel might trigger ME/CFS could help identify at-risk populations and inform prevention strategies.
This study does not prove that CMV or EBV causes ME/CFS, only that an association may exist in travelers. Observational data cannot establish causation, and the study does not account for confounding factors or compare infection rates in travelers with and without fatigue symptoms. Additionally, findings in tropical travelers may not generalize to the broader ME/CFS population.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Gascón, J, Marcos, T, Vidal, J, Garcia-Forcada, A, & Corachán, M (1995). Cytomegalovirus and Epstein-Barr Virus Infection as a Cause of Chronic Fatigue Syndrome in Travelers to Tropical Countries.. Journal of travel medicine. https://doi.org/10.1111/j.1708-8305.1995.tb00619.x
BibTeX
@article{mecfsatlas-gascn-1995-cytomegalovirus-epstein,
author = {Gascón, J and Marcos, T and Vidal, J and Garcia-Forcada, A and Corachán, M},
title = {Cytomegalovirus and Epstein-Barr Virus Infection as a Cause of Chronic Fatigue Syndrome in Travelers to Tropical Countries.},
journal = {Journal of travel medicine},
year = {1995},
doi = {10.1111/j.1708-8305.1995.tb00619.x},
note = {PubMed: 9815359},
url = {https://www.mecfsatlas.com/evidence/gascn-1995-cytomegalovirus-epstein},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/gascn-1995-cytomegalovirus-epstein
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