Greenlee, J E, Rose, J W · Seminars in neurology · 2000 · DOI
This is a review article that discusses six controversial topics in infections affecting the nervous system. One of these topics is whether viruses might play a role in chronic fatigue syndrome (ME/CFS). The authors examine what scientists know and disagree about regarding these infections and their treatments.
This review is historically significant because it documents that viral infection was recognized as a controversial hypothesis in ME/CFS research by major neurological authorities at the turn of the millennium. It highlights that infectious triggers for ME/CFS have been a persistent area of scientific investigation, legitimizing this research direction within neurology.
This review does not prove that viruses cause ME/CFS—it only documents that this was a debated hypothesis. It is a review of existing literature rather than original research presenting new evidence. The 2000 publication date means it does not reflect more recent findings about ME/CFS pathophysiology.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Greenlee, J E & Rose, J W (2000). Controversies in neurological infectious diseases.. Seminars in neurology. https://doi.org/10.1055/s-2000-9429
BibTeX
@article{mecfsatlas-greenlee-2000-controversies-neurological,
author = {Greenlee, J E and Rose, J W},
title = {Controversies in neurological infectious diseases.},
journal = {Seminars in neurology},
year = {2000},
doi = {10.1055/s-2000-9429},
note = {PubMed: 11051301},
url = {https://www.mecfsatlas.com/evidence/greenlee-2000-controversies-neurological},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/greenlee-2000-controversies-neurological
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