He, Min, Chen, Wenwen, Wang, Mengmeng et al. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2017 · DOI
Researchers developed a precise laboratory test to measure seven active ingredients from Bu-zhong-yi-qi-tang, a traditional herbal medicine used in East Asia for digestive problems, cancer, and chronic fatigue. They gave this herb to rats and tracked where these ingredients ended up in the body, finding they concentrated mainly in the digestive system.
Bu-zhong-yi-qi-tang is specifically used clinically to treat chronic fatigue syndrome, particularly in East Asian medical traditions. Understanding how individual components from this herbal formula distribute in body tissues is essential for determining which ingredients may be responsible for therapeutic effects and optimizing formulation design for ME/CFS patients.
This study does not demonstrate that Bu-zhong-yi-qi-tang is effective for treating ME/CFS—it only maps where the herb's ingredients go in the body after oral administration. The study used healthy rats rather than disease models, so it cannot establish whether these tissue distributions are therapeutically relevant to fatigue or immunological dysfunction in ME/CFS patients. The concentration of components in the gastrointestinal tract does not explain their mechanisms of action or clinical benefit.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
He, Min, Chen, Wenwen, Wang, Mengmeng, Wu, Yu, Zeng, Jin, Zhang, Zhirong, et al. (2017). Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. https://doi.org/10.1016/j.jchromb.2017.01.023
BibTeX
@article{mecfsatlas-he-2017-simultaneous-determination,
author = {He, Min and Chen, Wenwen and Wang, Mengmeng and Wu, Yu and Zeng, Jin and Zhang, Zhirong and Shen, Shujiao and Jiang, Jian},
title = {Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC-MS/MS: Application to a tissue distribution study.},
journal = {Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
year = {2017},
doi = {10.1016/j.jchromb.2017.01.023},
note = {PubMed: 28113140},
url = {https://www.mecfsatlas.com/evidence/he-2017-simultaneous-determination},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/he-2017-simultaneous-determination
Contribute
Private, reviewed by a human. Not a public comment thread.