Holecek, V, Rokyta, R · Ceskoslovenska fysiologie · 2016
This review article provides an overview of ME/CFS, explaining what it is, how common it is, and how doctors diagnose and treat it. The condition lasts about 6 months or longer in adults and at least 3 months in children, causing persistent fatigue and other symptoms. The article covers multiple possible causes including biological, genetic, infectious, and psychological factors, as well as the economic impact of the disease.
This review provides ME/CFS patients and healthcare providers with a comprehensive overview of the disease in one accessible resource, covering diagnosis, treatment options, and current understanding of its causes. For researchers, it synthesizes existing knowledge and identifies areas where understanding remains incomplete.
As a review article rather than an original research study, this paper does not present new experimental evidence or clinical data. It cannot establish causation or definitively prove which proposed mechanisms actually underlie ME/CFS pathophysiology. The article summarizes existing literature but does not test new hypotheses.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Holecek, V & Rokyta, R (2016). [Chronic fatifue syndrome.].. Ceskoslovenska fysiologie. https://pubmed.ncbi.nlm.nih.gov/29489084/
BibTeX
@article{mecfsatlas-holecek-2016-chronic-fatifue,
author = {Holecek, V and Rokyta, R},
title = {[Chronic fatifue syndrome.].},
journal = {Ceskoslovenska fysiologie},
year = {2016},
note = {PubMed: 29489084},
url = {https://www.mecfsatlas.com/evidence/holecek-2016-chronic-fatifue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/holecek-2016-chronic-fatifue
Contribute
Private, reviewed by a human. Not a public comment thread.