Iijima, Mami, Miyagaki, Tomomitsu, Nakajima, Kaori et al. · Cureus · 2025 · DOI
This case report describes one patient who developed psoriasis (a skin condition), sacroiliitis (inflammation of joints in the lower back), and ME/CFS all around the same time. The researchers reviewed what is known about how these three conditions might be connected through shared immune system problems. The study suggests that people with psoriasis may be at higher risk of developing ME/CFS, possibly because both conditions involve similar types of inflammatory immune responses.
Understanding connections between inflammatory skin conditions and ME/CFS may help identify patients at risk and guide future research into common immune mechanisms. This work supports the growing evidence that ME/CFS has immunological roots and may share pathways with other inflammatory disorders, potentially opening new avenues for diagnosis and treatment.
This single case report does not prove that psoriasis causes ME/CFS or sacroiliitis. Correlation observed in one patient cannot establish causation, and individual cases cannot determine whether these conditions share a common cause, occur sequentially, or are coincidental. Larger controlled studies are needed to confirm any causal relationships.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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