Innabi, Ayoub, Alzghoul, Bashar N, Kalra, Saminder et al. · Respiratory medicine · 2021 · DOI
This study looked at how sarcoidosis (a disease that causes inflammation in the body) affects Hispanic patients in the United States compared to non-Hispanic patients. Researchers surveyed nearly 3,835 people and found that Hispanic patients with sarcoidosis experience more depression, chronic pain, sleep problems, and job loss than non-Hispanic patients. The findings suggest that doctors may need to approach treatment differently for Hispanic patients with this condition.
While this study focuses on sarcoidosis rather than ME/CFS, it is relevant because both conditions involve multi-system inflammation, fatigue, neurological symptoms, and significant functional disability that disproportionately affects employment and mental health. The findings highlight how ethnicity influences disease burden and socioeconomic outcomes in chronic systemic illnesses, informing more equitable clinical approaches and suggesting that ME/CFS research should similarly examine disparities across ethnic groups.
This study does not establish that Hispanic ethnicity causes worse sarcoidosis outcomes or depression—it only documents an association. The registry's self-reported, web-based design may introduce selection bias, and the analysis cannot rule out confounding by disease severity, healthcare access, socioeconomic factors not fully captured, or differences in symptom reporting. Findings are specific to sarcoidosis and cannot be directly extrapolated to ME/CFS without independent validation.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Innabi, Ayoub, Alzghoul, Bashar N, Kalra, Saminder, Al-Hakim, Tamara, Buchanan, Mindy, Shivas, Tricha, et al. (2021). Sarcoidosis among US Hispanics in a Nationwide Registry.. Respiratory medicine. https://doi.org/10.1016/j.rmed.2021.106682
BibTeX
@article{mecfsatlas-innabi-2021-sarcoidosis-among,
author = {Innabi, Ayoub and Alzghoul, Bashar N and Kalra, Saminder and Al-Hakim, Tamara and Buchanan, Mindy and Shivas, Tricha and Xue, Wei and Gomez-Manjarres, Diana and Patel, Divya C},
title = {Sarcoidosis among US Hispanics in a Nationwide Registry.},
journal = {Respiratory medicine},
year = {2021},
doi = {10.1016/j.rmed.2021.106682},
note = {PubMed: 34788736},
url = {https://www.mecfsatlas.com/evidence/innabi-2021-sarcoidosis-among},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/innabi-2021-sarcoidosis-among
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