ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

1–20 of 240 studies

Sorted by evidence level and year

E0 ConsensusReviewPEM unclearSystematic-Review

A systematic scoping review and conceptual analysis of new-onset fibromyalgia manifestations after non-hospitalized COVID-19: empirics, definitions, methodologies, pathophysiology, mapping of literature, and knowledge gaps.

Plaut, Shiloh·Journal of translational medicine·2026

This systematic review examined published studies on fibromyalgia-like symptoms that develop after mild COVID-19 infection. Researchers searched medical databases and found 228 studies reporting overlap between long COVID, chronic fatigue, and fibromyalgia, but noted that different studies use inconsistent definitions and methods, making it difficult to draw firm conclusions. The causes of these overlapping conditions remain unclear.

NeuroinflammationPain and SensitizationImmune SystemLong COVID Overlap

E0 ConsensusReviewPEM not requiredSystematic-Review

Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.

Lepri, Beatrice, Romani, Daniele, Storari, Lorenzo et al.·International journal of environmental research and public health·2023

This review looked at 15 studies testing whether pain neuroscience education—teaching patients how pain works in the nervous system—helps people with chronic muscle and joint pain, including those with conditions like fibromyalgia and chronic fatigue syndrome. The research found that this type of education does appear to reduce pain and improve disability and mood, especially when delivered one-on-one and combined with other treatments like physical therapy.

Evidence Atlas

Evidence browser

A systematic scoping review and conceptual analysis of new-onset fibromyalgia manifestations after non-hospitalized COVID-19: empirics, definitions, methodologies, pathophysiology, mapping of literature, and knowledge gaps.

Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.

A systematic review on the health outcomes associated with non-endocarditis manifestations of chronic Q fever.

Interventions to treat pain in paediatric CFS/ME: a systematic review.

Identification of mental health and quality of life outcomes in primary care databases in the UK: a systematic review.

Pathophysiology of interstitial cystitis.

Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study.

Yoga intervention and functional pain syndromes: a selective review.

Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature.

Chronic Pelvic Pain in Women.

Gynecological disorders in bladder pain syndrome/interstitial cystitis patients.

Bladder pain syndrome/interstitial cystitis as a functional somatic syndrome.

Dysfunctional syndromes and fibromyalgia: a 2012 critical digest.

The prevalence of fibromyalgia in other chronic pain conditions.

Sleep, pain, fibromyalgia, and chronic fatigue syndrome.

Systematic review of multi-symptom conditions in Gulf War veterans.

Genetic factors in neuromuscular pain.

Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms.

Fibromyalgia syndrome, idiopathic widespread persistent pain or syndrome of myalgic encephalomyelopathy (SME): what is its nature?

[What happens to the fibromyalgia syndrome?].

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research