Janežič, Dušanka, Jäntschi, Lorentz, Bolboacă, Sorana D · Current medicinal chemistry · 2020 · DOI
This study reviews how different types of sugars and sweeteners affect health, including their possible links to chronic fatigue syndrome (ME/CFS). The researchers explain that each sugar and sweetener is processed differently by the body based on its chemical structure, and they used computer models to help understand and predict how these substances might affect health.
Understanding how different sugars and sweeteners are metabolized could help ME/CFS patients make informed dietary choices. Since metabolic dysfunction is implicated in ME/CFS, identifying which specific compounds may worsen or improve symptoms based on their chemical structure could support personalized dietary management strategies.
This review does not establish a causal relationship between specific sugars/sweeteners and ME/CFS—it identifies an association noted in literature. The study does not provide clinical trial data proving that eliminating or adding particular sweeteners will improve ME/CFS symptoms. Individual responses to sugars vary widely, so conclusions cannot be universally applied to all patients.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Janežič, Dušanka, Jäntschi, Lorentz, & Bolboacă, Sorana D (2020). Sugars and Sweeteners: Structure, Properties and In Silico Modeling.. Current medicinal chemistry. https://doi.org/10.2174/0929867325666180926144401
BibTeX
@article{mecfsatlas-janei-2020-sugars-sweeteners,
author = {Janežič, Dušanka and Jäntschi, Lorentz and Bolboacă, Sorana D},
title = {Sugars and Sweeteners: Structure, Properties and In Silico Modeling.},
journal = {Current medicinal chemistry},
year = {2020},
doi = {10.2174/0929867325666180926144401},
note = {PubMed: 30259809},
url = {https://www.mecfsatlas.com/evidence/janei-2020-sugars-sweeteners},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/janei-2020-sugars-sweeteners
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