Kato, Y, Kamijima, S, Kashiwagi, A et al. · Nihon rinsho. Japanese journal of clinical medicine · 1992
This study describes two women with ME/CFS who had unusual medical findings. One woman had very high levels of antibodies to HHV-6, a virus that may reactivate in ME/CFS patients. The second woman's ME/CFS symptoms improved when she had high blood pressure and a hormone imbalance, but her symptoms returned after surgery to remove an adrenal gland. These cases suggest that viruses and hormones might play a role in ME/CFS, though more research is needed to understand how.
These cases provide clinical observations that link ME/CFS to potentially modifiable factors—viral reactivation and hormonal dysregulation—that warrant further investigation. If confirmed in larger studies, these findings could suggest new diagnostic markers or treatment approaches for ME/CFS patients who have not responded to standard care.
Case reports cannot prove causation or establish how common these findings are in ME/CFS populations. The relationship between HHV-6 titers and CFS symptoms, or between aldosterone levels and CFS severity, remains correlational and unproven. These two cases cannot be generalized to all ME/CFS patients, and the temporal associations described may reflect coincidence rather than biological causation.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Kato, Y, Kamijima, S, Kashiwagi, A, & Oguri, T (1992). [Chronic fatigue syndrome, a case of high anti-HHV-6 antibody titer and one associated with primary hyperaldosteronism].. Nihon rinsho. Japanese journal of clinical medicine. https://pubmed.ncbi.nlm.nih.gov/1337563/
BibTeX
@article{mecfsatlas-kato-1992-chronic-fatigue,
author = {Kato, Y and Kamijima, S and Kashiwagi, A and Oguri, T},
title = {[Chronic fatigue syndrome, a case of high anti-HHV-6 antibody titer and one associated with primary hyperaldosteronism].},
journal = {Nihon rinsho. Japanese journal of clinical medicine},
year = {1992},
note = {PubMed: 1337563},
url = {https://www.mecfsatlas.com/evidence/kato-1992-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/kato-1992-chronic-fatigue
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