Kern, Janet K, Geier, David A, Bjørklund, Geir et al. · Neuro endocrinology letters · 2014
This review article examines whether mercury vapor released from dental fillings (amalgams) might cause or worsen ME/CFS, fibromyalgia, depression, and anxiety. The authors found that studies linking mercury exposure to fatigue, anxiety, and depression symptoms are similar to what people experience with ME/CFS, and that some patients improved after having their amalgam fillings removed. The authors conclude that mercury from dental fillings deserves serious consideration when investigating chronic fatigue and related conditions.
For ME/CFS patients experiencing depression and anxiety, understanding potential environmental triggers like mercury exposure could inform clinical investigation and management strategies. The review highlights that careful dental history and consideration of amalgam-related toxicity may be relevant in evaluating chronic fatigue cases, potentially opening new avenues for some patients' clinical care.
This review does not prove that dental amalgams cause ME/CFS or that amalgam removal will improve ME/CFS symptoms in most patients. It is a literature review without original clinical data or randomized controlled trials, so it cannot establish definitive causation or quantify the actual risk of amalgam exposure. The selective citation of supporting studies without systematic review methodology means the full weight of scientific evidence remains unclear.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Kern, Janet K, Geier, David A, Bjørklund, Geir, King, Paul G, Homme, Kristin G, Haley, Boyd E, et al. (2014). Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.. Neuro endocrinology letters. https://pubmed.ncbi.nlm.nih.gov/25617876/
BibTeX
@article{mecfsatlas-kern-2014-evidence-supporting,
author = {Kern, Janet K and Geier, David A and Bjørklund, Geir and King, Paul G and Homme, Kristin G and Haley, Boyd E and Sykes, Lisa K and Geier, Mark R},
title = {Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide.},
journal = {Neuro endocrinology letters},
year = {2014},
note = {PubMed: 25617876},
url = {https://www.mecfsatlas.com/evidence/kern-2014-evidence-supporting},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/kern-2014-evidence-supporting
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