Kerr, Jonathan R, Petty, Robert, Burke, Beverley et al. · The Journal of infectious diseases · 2008 · DOI
Researchers analyzed blood samples from 25 ME/CFS patients and 50 healthy people to look for differences in which genes were active. They found that 88 genes behaved differently in ME/CFS patients compared to healthy controls—most were working overtime, while a few were underactive. When they studied a larger group, they discovered that ME/CFS patients could be divided into 7 distinct subtypes based on their gene activity patterns, and these subtypes differed in symptom severity and how the illness affected their daily lives.
This study provides objective molecular evidence that ME/CFS is not a single homogeneous condition but comprises multiple biological subtypes, which could explain why patients respond differently to treatments. Identifying gene expression signatures offers potential for developing blood-based diagnostic tests and personalized treatment strategies tailored to individual molecular profiles.
This study does not establish whether the observed gene expression changes cause ME/CFS symptoms or merely reflect the disease state—the direction of causality remains unknown. The study does not prove these gene expression patterns are stable over time or predict clinical outcomes. It also does not demonstrate that targeting these genes therapeutically would improve patient outcomes.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Kerr, Jonathan R, Petty, Robert, Burke, Beverley, Gough, John, Fear, David, Sinclair, Lindsey I, et al. (2008). Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.. The Journal of infectious diseases. https://doi.org/10.1086/533453
BibTeX
@article{mecfsatlas-kerr-2008-gene-expression,
author = {Kerr, Jonathan R and Petty, Robert and Burke, Beverley and Gough, John and Fear, David and Sinclair, Lindsey I and Mattey, Derek L and Richards, Selwyn C M and Montgomery, Jane and Baldwin, Don A and Kellam, Paul and Harrison, Tim J and Griffin, George E and Main, Janice and Enlander, Derek and Nutt, David J and Holgate, Stephen T},
title = {Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.},
journal = {The Journal of infectious diseases},
year = {2008},
doi = {10.1086/533453},
note = {PubMed: 18462164},
url = {https://www.mecfsatlas.com/evidence/kerr-2008-gene-expression},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/kerr-2008-gene-expression
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