Lacerda, Eliana M, Bowman, Erinna W, Cliff, Jacqueline M et al. · Open journal of bioresources · 2017 · DOI
The UK ME/CFS Biobank is a collection of blood samples and health information from 284 people with ME/CFS, 60 people with multiple sclerosis, and 135 healthy volunteers. Researchers created this resource to help scientists study what causes ME/CFS and find better ways to diagnose and treat it. The samples and detailed patient information can be used by researchers worldwide to search for biological markers of the disease.
This biobank addresses a critical gap in ME/CFS research by providing standardized, high-quality biological samples linked to detailed clinical data, enabling systematic investigation of disease mechanisms that have remained poorly understood. For patients, this resource accelerates the search for diagnostic biomarkers and potential therapeutic targets that could lead to better disease recognition and treatment options. The inclusion of MS cases as a comparator also helps distinguish ME/CFS-specific biological signatures from features common to other neurological conditions.
This study does not prove what causes ME/CFS or identify specific disease mechanisms—it only provides the infrastructure and samples for such research to occur. The biobank design does not establish correlations between any biological markers and disease severity or outcomes; such findings would require analysis studies conducted by subsequent researchers. The cross-sectional nature of sample collection means this resource cannot establish causality or temporal relationships between biological changes and symptom development.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lacerda, Eliana M, Bowman, Erinna W, Cliff, Jacqueline M, Kingdon, Caroline C, King, Elizabeth C, Lee, Ji-Sook, et al. (2017). The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis.. Open journal of bioresources. https://doi.org/10.5334/ojb.28
BibTeX
@article{mecfsatlas-lacerda-2017-cfs-biobank,
author = {Lacerda, Eliana M and Bowman, Erinna W and Cliff, Jacqueline M and Kingdon, Caroline C and King, Elizabeth C and Lee, Ji-Sook and Clark, Taane G and Dockrell, Hazel M and Riley, Eleanor M and Curran, Hayley and Nacul, Luis},
title = {The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis.},
journal = {Open journal of bioresources},
year = {2017},
doi = {10.5334/ojb.28},
note = {PubMed: 28649428},
url = {https://www.mecfsatlas.com/evidence/lacerda-2017-cfs-biobank},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/lacerda-2017-cfs-biobank
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