Larun, Lillebeth, Brurberg, Kjetil G, Odgaard-Jensen, Jan et al. · The Cochrane database of systematic reviews · 2015 · DOI
This review looked at eight studies involving 1,518 people with ME/CFS to see whether exercise therapy helps. The researchers found that people who did exercise therapy reported feeling less fatigued and experienced improvements in sleep, physical functioning, and overall health compared to those receiving no special treatment. Exercise therapy appeared safe, with no serious harmful effects reported, though the studies had some limitations.
This systematic review provides the most comprehensive synthesis of exercise therapy evidence in ME/CFS and helps clinicians and patients understand whether structured exercise is a safe and effective treatment option. The findings are important because exercise is commonly recommended for ME/CFS, yet the evidence base had not been systematically reviewed since 2004, and concerns about harm remain among some patient communities.
This review does not establish that exercise is universally beneficial for all ME/CFS patients, nor does it identify the optimal type, intensity, or duration of exercise for different patient subgroups. The review also cannot determine whether benefits persist long-term after therapy ends, as most studies measured only end-of-treatment outcomes. Additionally, the sparse data on serious adverse events means we cannot definitively rule out the possibility of harm in vulnerable subpopulations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Larun, Lillebeth, Brurberg, Kjetil G, Odgaard-Jensen, Jan, & Price, Jonathan R (2015). Exercise therapy for chronic fatigue syndrome.. The Cochrane database of systematic reviews. https://doi.org/10.1002/14651858.CD003200.pub3
BibTeX
@article{mecfsatlas-larun-2015-exercise-therapy,
author = {Larun, Lillebeth and Brurberg, Kjetil G and Odgaard-Jensen, Jan and Price, Jonathan R},
title = {Exercise therapy for chronic fatigue syndrome.},
journal = {The Cochrane database of systematic reviews},
year = {2015},
doi = {10.1002/14651858.CD003200.pub3},
note = {PubMed: 25674924},
url = {https://www.mecfsatlas.com/evidence/larun-2015-exercise-therapy},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/larun-2015-exercise-therapy
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