Leong, Pou Kuan, Wong, Hoi Shan, Chen, Jihang et al. · Evidence-based complementary and alternative medicine : eCAM · 2015 · DOI
This study explores whether certain Chinese herbal medicines might help ME/CFS by improving how cells produce energy. The researchers suggest that traditional concepts of 'Yang' and 'Qi' deficiency in Chinese medicine may relate to mitochondrial problems (the energy-producing parts of cells) seen in ME/CFS. They propose that specific herbs like Cistanches and Schisandrae might boost mitochondrial function and help patients with fatigue.
This work is significant because it attempts to create a mechanistic framework linking traditional medicine concepts to modern understanding of ME/CFS pathology. For patients, it raises the possibility of therapeutic approaches grounded in both traditional and modern science. For researchers, it suggests avenues for investigating whether specific herbal compounds can modulate mitochondrial dysfunction in ME/CFS.
This study does not prove that herbal therapies are effective for ME/CFS, nor does it demonstrate that Yang/Qi deficiency and mitochondrial dysfunction are the same phenomenon. It presents no clinical trial data, no patient outcomes, and no direct experimental evidence linking these specific herbs to improved ME/CFS symptoms. The theoretical framework remains speculative without empirical validation.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Leong, Pou Kuan, Wong, Hoi Shan, Chen, Jihang, & Ko, Kam Ming (2015). Yang/Qi invigoration: an herbal therapy for chronic fatigue syndrome with yang deficiency?. Evidence-based complementary and alternative medicine : eCAM. https://doi.org/10.1155/2015/945901
BibTeX
@article{mecfsatlas-leong-2015-yang-invigoration,
author = {Leong, Pou Kuan and Wong, Hoi Shan and Chen, Jihang and Ko, Kam Ming},
title = {Yang/Qi invigoration: an herbal therapy for chronic fatigue syndrome with yang deficiency?},
journal = {Evidence-based complementary and alternative medicine : eCAM},
year = {2015},
doi = {10.1155/2015/945901},
note = {PubMed: 25763095},
url = {https://www.mecfsatlas.com/evidence/leong-2015-yang-invigoration},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/leong-2015-yang-invigoration
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