Li, De-Qiang, Li, Zhong-Chun, Dai, Zhi-Yuan · International journal of clinical and experimental medicine · 2015
Researchers tested whether combining an antidepressant medication (SSRI) with a traditional Chinese herbal supplement called Dengzhanshengmai could help ME/CFS patients better than the antidepressant alone. Over 12 weeks, patients taking both treatments showed faster and greater improvement in physical fatigue, general tiredness, and motivation compared to those taking only the antidepressant, though both groups had similar side effects overall.
This study provides evidence that adjunctive herbal treatment may enhance SSRI efficacy in reducing core ME/CFS fatigue symptoms, potentially offering patients a more effective therapeutic option. Understanding combination approaches is important because single-agent treatments often produce incomplete symptom relief in ME/CFS populations.
This study does not prove Dengzhanshengmai works alone, as it tested only the combination with SSRI; it cannot establish causality due to its open-label design without placebo control, making it vulnerable to expectancy effects. The generalizability to ME/CFS populations outside China remains unclear, and the mechanism of any benefit is not established.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Li, De-Qiang, Li, Zhong-Chun, & Dai, Zhi-Yuan (2015). Selective serotonin reuptake inhibitor combined with dengzhanshengmai capsule improves the fatigue symptoms: a 12-week open-label pilot study.. International journal of clinical and experimental medicine. https://pubmed.ncbi.nlm.nih.gov/26380022/
BibTeX
@article{mecfsatlas-li-2015-selective-serotonin,
author = {Li, De-Qiang and Li, Zhong-Chun and Dai, Zhi-Yuan},
title = {Selective serotonin reuptake inhibitor combined with dengzhanshengmai capsule improves the fatigue symptoms: a 12-week open-label pilot study.},
journal = {International journal of clinical and experimental medicine},
year = {2015},
note = {PubMed: 26380022},
url = {https://www.mecfsatlas.com/evidence/li-2015-selective-serotonin},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/li-2015-selective-serotonin
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