Li, Yan-Hui, Ma, Qiao-Lin, Hu, Bin et al. · Zhen ci yan jiu = Acupuncture research · 2021 · DOI
This review examined research from the past 10 years on how acupuncture may help chronic fatigue syndrome by looking at four main body systems: immune function, stress hormones and brain chemistry, the body's ability to handle cellular damage, and cell signaling pathways. The researchers found evidence that acupuncture appears to work through multiple mechanisms rather than just one, potentially helping the body recover from CFS through different pathways.
Understanding the biological mechanisms behind acupuncture's effects could help validate it as a therapeutic option for ME/CFS patients and guide development of more targeted treatments. For researchers, this synthesis suggests multiple interconnected biological systems are involved in CFS pathophysiology, which may explain why single-target interventions have had limited success.
This review does not establish that acupuncture is definitively effective for CFS, as it synthesizes mostly mechanistic studies rather than rigorous clinical trials. The presence of identified biological changes does not prove these changes are responsible for symptom improvement, and publication bias may favor studies reporting positive findings. Individual study quality and evidence levels are not critically evaluated.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Li, Yan-Hui, Ma, Qiao-Lin, Hu, Bin, & Wang, Zhong-Lei (2021). [Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].. Zhen ci yan jiu = Acupuncture research. https://doi.org/10.13702/j.1000-0607.200998
BibTeX
@article{mecfsatlas-li-2021-current-state,
author = {Li, Yan-Hui and Ma, Qiao-Lin and Hu, Bin and Wang, Zhong-Lei},
title = {[Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome].},
journal = {Zhen ci yan jiu = Acupuncture research},
year = {2021},
doi = {10.13702/j.1000-0607.200998},
note = {PubMed: 34865338},
url = {https://www.mecfsatlas.com/evidence/li-2021-current-state},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/li-2021-current-state
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