Li, Jingnan, Piao, Feng, Zeng, Qiaoqiao et al. · Medicine · 2024 · DOI
Researchers reviewed 32 studies involving nearly 2,600 ME/CFS patients to see if massage therapy helps reduce fatigue. They found that massage significantly improved fatigue scores on standardized tests, with patients in the massage group showing better results than control groups. Massage appeared safe, with very few adverse effects reported.
This comprehensive review synthesizes evidence on a non-pharmacological intervention widely accessible to ME/CFS patients seeking symptom management. The large pooled sample size and significant effect sizes across multiple fatigue domains suggest massage warrants consideration as a supportive therapy, though rigorous replication in international populations is needed.
This systematic review does not establish causal mechanisms by which massage improves fatigue in ME/CFS. The meta-analysis cannot determine whether improvements persist long-term, whether massage can prevent post-exertional malaise, or whether benefits generalize beyond the Chinese healthcare settings where most trials were conducted. Publication bias and selective adverse event reporting may inflate reported safety.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Li, Jingnan, Piao, Feng, Zeng, Qiaoqiao, Yan, Huixin, Bi, Yunpeng, Zhang, Shaobo, et al. (2024). The effect of massage on patients with chronic fatigue syndrome: A systematic review and meta-analysis.. Medicine. https://doi.org/10.1097/MD.0000000000037973
BibTeX
@article{mecfsatlas-li-2024-effect-massage,
author = {Li, Jingnan and Piao, Feng and Zeng, Qiaoqiao and Yan, Huixin and Bi, Yunpeng and Zhang, Shaobo and Song, Bailin},
title = {The effect of massage on patients with chronic fatigue syndrome: A systematic review and meta-analysis.},
journal = {Medicine},
year = {2024},
doi = {10.1097/MD.0000000000037973},
note = {PubMed: 38701244},
url = {https://www.mecfsatlas.com/evidence/li-2024-effect-massage},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/li-2024-effect-massage
Contribute
Private, reviewed by a human. Not a public comment thread.