Lintas, Carla, Guidi, Francesco, Manzi, Barbara et al. · PloS one · 2011 · DOI
Researchers wanted to know if a virus called XMRV or related viruses might cause autism. They tested blood, brain tissue, and semen samples from people with autism, their fathers, and control groups. They found no evidence that XMRV or similar viruses were present in autism patients, suggesting these viruses are unlikely to play a role in causing autism.
Although this study focused on autism rather than ME/CFS, it is relevant because XMRV was simultaneously being investigated as a potential cause of chronic fatigue syndrome. This negative finding in autism helps clarify the broader question of whether XMRV is a significant human pathogen. Understanding whether proposed viral candidates are actually involved in complex conditions helps guide research priorities in both autism and ME/CFS.
This study does not prove that XMRV or MLV viruses play no role in ME/CFS or other conditions—it only tested autism samples. The absence of detection does not rule out infection in other patient populations or tissues not sampled. It also does not establish that other viruses are not involved in autism pathogenesis.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lintas, Carla, Guidi, Francesco, Manzi, Barbara, Mancini, Antonio, Curatolo, Paolo, & Persico, Antonio M (2011). Lack of infection with XMRV or other MLV-related viruses in blood, post-mortem brains and paternal gametes of autistic individuals.. PloS one. https://doi.org/10.1371/journal.pone.0016609
BibTeX
@article{mecfsatlas-lintas-2011-lack-infection,
author = {Lintas, Carla and Guidi, Francesco and Manzi, Barbara and Mancini, Antonio and Curatolo, Paolo and Persico, Antonio M},
title = {Lack of infection with XMRV or other MLV-related viruses in blood, post-mortem brains and paternal gametes of autistic individuals.},
journal = {PloS one},
year = {2011},
doi = {10.1371/journal.pone.0016609},
note = {PubMed: 21373179},
url = {https://www.mecfsatlas.com/evidence/lintas-2011-lack-infection},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/lintas-2011-lack-infection
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