Logan, Alan C, Beaulne, Tracey M · Alternative medicine review : a journal of clinical therapeutic · 2002
This study describes one patient who had too many bacteria growing in their small intestine and was experiencing IBS-like symptoms. When treated with enteric-coated peppermint oil (a special form of peppermint that reaches the small intestine), the patient felt significantly better and had measurable improvements in digestive gas production. This suggests peppermint oil might work by reducing harmful bacteria in the gut.
Since SIBO has been associated with ME/CFS, IBS, and fibromyalgia, this case raises the possibility that a readily available, natural intervention might help address a potential underlying mechanism in these conditions. The observation that peppermint oil reduces bacterial overgrowth could inform future research into gut-based therapies for ME/CFS patients.
This case report does not prove that peppermint oil is effective for SIBO or ME/CFS in general—it describes only one patient's response. It does not establish whether symptom improvement resulted from reduced bacterial load, placebo effect, or other factors. The study cannot determine whether SIBO is a primary cause of ME/CFS symptoms or an incidental finding.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Logan, Alan C & Beaulne, Tracey M (2002). The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: a case report.. Alternative medicine review : a journal of clinical therapeutic. https://pubmed.ncbi.nlm.nih.gov/12410625/
BibTeX
@article{mecfsatlas-logan-2002-treatment-small,
author = {Logan, Alan C and Beaulne, Tracey M},
title = {The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: a case report.},
journal = {Alternative medicine review : a journal of clinical therapeutic},
year = {2002},
note = {PubMed: 12410625},
url = {https://www.mecfsatlas.com/evidence/logan-2002-treatment-small},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/logan-2002-treatment-small
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