Lopez, Corina, Antoni, Michael, Penedo, Frank et al. · Journal of psychosomatic research · 2011 · DOI
This study tested whether a 12-week stress management program could help people with ME/CFS feel better. Participants either attended cognitive behavioral stress management classes or educational seminars. People in the stress management program reported less stress, better mood, improved quality of life, and reduced symptom severity compared to those in the educational group.
This study addresses the psychological burden accompanying ME/CFS and provides evidence that stress management may reduce both distress and disease symptom severity. For patients seeking non-pharmacological approaches to managing ME/CFS-related suffering, this research suggests cognitive behavioral interventions warrant further investigation.
This study does not prove that stress causes ME/CFS or that stress reduction permanently cures it. The small pilot sample and short 12-week follow-up window mean results may not apply broadly to all ME/CFS populations, and longer-term sustainability of benefits remains undemonstrated. The mechanisms by which CBSM reduces symptom severity remain unclear.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lopez, Corina, Antoni, Michael, Penedo, Frank, Weiss, Donna, Cruess, Stacy, Segotas, Mary-Catherine, et al. (2011). A pilot study of cognitive behavioral stress management effects on stress, quality of life, and symptoms in persons with chronic fatigue syndrome.. Journal of psychosomatic research. https://doi.org/10.1016/j.jpsychores.2010.11.010
BibTeX
@article{mecfsatlas-lopez-2011-pilot-study,
author = {Lopez, Corina and Antoni, Michael and Penedo, Frank and Weiss, Donna and Cruess, Stacy and Segotas, Mary-Catherine and Helder, Lynn and Siegel, Scott and Klimas, Nancy and Fletcher, Mary Ann},
title = {A pilot study of cognitive behavioral stress management effects on stress, quality of life, and symptoms in persons with chronic fatigue syndrome.},
journal = {Journal of psychosomatic research},
year = {2011},
doi = {10.1016/j.jpsychores.2010.11.010},
note = {PubMed: 21414452},
url = {https://www.mecfsatlas.com/evidence/lopez-2011-pilot-study},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/lopez-2011-pilot-study
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