Lozano de León, F, Gutiérrez Fernández, J, Martín Mazuelos, E et al. · Revista clinica espanola · 1992
This review summarizes what scientists know about human herpesvirus type 6 (HHV-6), a common virus that most people carry their whole lives. The virus can cause rash illnesses in children and mono-like symptoms in adults, and some research suggests it might play a role in chronic fatigue syndrome and other long-term illnesses.
This work is historically important because it was among the early scientific discussions linking HHV-6 reactivation to ME/CFS pathogenesis. For patients and researchers, it highlights why investigating herpesvirus infections remains relevant to understanding potential biological mechanisms in chronic fatigue syndrome.
This review does not prove that HHV-6 causes ME/CFS—it only proposes that persistent infection may 'influence' the development of chronic fatigue syndrome under certain conditions. The abstract provides no original data, clinical trials, or mechanistic evidence, and the association between HHV-6 and ME/CFS remains unproven and contested in subsequent decades of research.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lozano de León, F, Gutiérrez Fernández, J, Martín Mazuelos, E, & García-Bragado, F (1992). [Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].. Revista clinica espanola. https://pubmed.ncbi.nlm.nih.gov/1312248/
BibTeX
@article{mecfsatlas-lozano-de-len-1992-infection-human,
author = {Lozano de León, F and Gutiérrez Fernández, J and Martín Mazuelos, E and García-Bragado, F},
title = {[Infection by human herpesvirus type 6: epidemiology, immunopathology and clinical implications].},
journal = {Revista clinica espanola},
year = {1992},
note = {PubMed: 1312248},
url = {https://www.mecfsatlas.com/evidence/lozano-de-len-1992-infection-human},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/lozano-de-len-1992-infection-human
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