Lu, Chen, Yang, Xiu-Juan, Hu, Jie · Zhen ci yan jiu = Acupuncture research · 2014
This study tested whether acupuncture and moxibustion (a traditional Chinese medicine technique using heat) could reduce fatigue in ME/CFS patients. 133 patients received either manual acupuncture, warm-needling (heated acupuncture), or treatment at non-acupuncture points as a control. Both active treatments reduced fatigue symptoms after 20 daily sessions, with warm-needling showing slightly better results than manual acupuncture.
ME/CFS patients have limited evidence-based treatment options, making exploration of complementary interventions important. This study provides quantitative evidence that acupuncture-based techniques may reduce fatigue severity, suggesting a potential therapeutic avenue worth investigating further in larger, international studies.
This study does not establish the mechanism by which acupuncture reduces fatigue or confirm that benefits persist beyond the immediate post-treatment period. The lack of long-term follow-up data, absence of blinding (patients knew which treatment they received), and lack of information about whether symptom improvements reflect genuine disease modification versus placebo response limit generalizability to Western ME/CFS populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lu, Chen, Yang, Xiu-Juan, & Hu, Jie (2014). [Randomized controlled clinical trials of acupuncture and moxibustion treatment of chronic fatigue syndrome patients].. Zhen ci yan jiu = Acupuncture research. https://pubmed.ncbi.nlm.nih.gov/25219128/
BibTeX
@article{mecfsatlas-lu-2014-randomized-controlled,
author = {Lu, Chen and Yang, Xiu-Juan and Hu, Jie},
title = {[Randomized controlled clinical trials of acupuncture and moxibustion treatment of chronic fatigue syndrome patients].},
journal = {Zhen ci yan jiu = Acupuncture research},
year = {2014},
note = {PubMed: 25219128},
url = {https://www.mecfsatlas.com/evidence/lu-2014-randomized-controlled},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/lu-2014-randomized-controlled
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