Lubell, Jeffrey · Journal of translational medicine · 2022 · DOI
This editorial letter explores whether problems with blood vessel function and damage might explain some of the key symptoms of ME/CFS, including pain, inflammation, and post-exertional malaise (the exhaustion that follows physical activity). The author proposes that if blood vessels aren't working properly, they may not deliver enough oxygen and nutrients to tissues, which could trigger the symptoms many ME/CFS patients experience.
This perspective is important because it connects vascular biology to ME/CFS symptoms in a way that may help explain why activity worsens symptoms and why inflammation is present. If endothelial dysfunction is confirmed as a contributing mechanism, it could open new avenues for treatment targeting blood vessel function and tissue perfusion.
This editorial does not provide experimental evidence that endothelial dysfunction actually occurs in ME/CFS patients or that it directly causes symptoms. It is a hypothesis-generating letter, not a study with patient data, so it cannot establish causation or quantify the contribution of vascular dysfunction to ME/CFS pathology.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lubell, Jeffrey (2022). Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?. Journal of translational medicine. https://doi.org/10.1186/s12967-022-03244-7
BibTeX
@article{mecfsatlas-lubell-2022-letter-could,
author = {Lubell, Jeffrey},
title = {Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)?},
journal = {Journal of translational medicine},
year = {2022},
doi = {10.1186/s12967-022-03244-7},
note = {PubMed: 35073915},
url = {https://www.mecfsatlas.com/evidence/lubell-2022-letter-could},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/lubell-2022-letter-could
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