Lyu, Yu Han, Li, Min, Yao, Hui Qing et al. · Biomedical and environmental sciences : BES · 2025 · DOI
This study examined whether pregnant people who had COVID-19 experienced more urinary symptoms (like leakage or urgency) after giving birth compared to those who didn't have COVID-19. Researchers surveyed 3,652 women at two hospitals in China and found that COVID-19 infection during pregnancy did not increase reported urinary problems. However, they did find that the muscles controlling urination showed different electrical activity in women who had COVID-19, suggesting the virus may affect how these muscles work at a deeper level.
Post-exertional malaise and fatigue are hallmark ME/CFS features, and emerging evidence suggests viral infections like COVID-19 may trigger post-viral complications affecting multiple organ systems. Understanding how SARS-CoV-2 influences neuromuscular function—even when clinical symptoms are absent—may illuminate mechanisms of post-viral autonomic and muscular dysfunction relevant to ME/CFS pathophysiology.
This study does not establish that LUTS will develop in COVID-infected women over longer follow-up periods, nor does it prove causation—the altered EMG findings are correlational. The absence of reported symptom differences does not rule out subclinical neuromuscular damage that could become clinically significant later. Additionally, the study was conducted in a specific population at two Chinese hospitals, limiting generalizability.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Lyu, Yu Han, Li, Min, Yao, Hui Qing, Gai, Tian Zi, Liang, Lin, Pan, Su, et al. (2025). Does Prenatal SARS-CoV-2 Infection Exacerbate Postpartum Lower Urinary Tract Symptoms? A Multicenter Retrospective Cohort Study.. Biomedical and environmental sciences : BES. https://doi.org/10.3967/bes2025.065
BibTeX
@article{mecfsatlas-lyu-2025-does-prenatal,
author = {Lyu, Yu Han and Li, Min and Yao, Hui Qing and Gai, Tian Zi and Liang, Lin and Pan, Su and Li, Ping Ping and Liang, Ya Xin and Yu, Yue and Wu, Xiao Mei and Li, Min},
title = {Does Prenatal SARS-CoV-2 Infection Exacerbate Postpartum Lower Urinary Tract Symptoms? A Multicenter Retrospective Cohort Study.},
journal = {Biomedical and environmental sciences : BES},
year = {2025},
doi = {10.3967/bes2025.065},
note = {PubMed: 41088815},
url = {https://www.mecfsatlas.com/evidence/lyu-2025-does-prenatal},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/lyu-2025-does-prenatal
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