Manuel y Keenoy, B, Moorkens, G, Vertommen, J et al. · Life sciences · 2001 · DOI
This study looked at whether oxidative stress—a type of cellular damage—might contribute to ME/CFS. Researchers compared 33 people with ME/CFS to 28 people with similar symptoms who didn't meet ME/CFS criteria. They found that people with ME/CFS had higher levels of fat damage in their blood particles and lower levels of a protective protein called transferrin, suggesting their bodies may be more vulnerable to oxidative damage.
This research provides early evidence that oxidative stress and lipid peroxidation may be involved in ME/CFS pathogenesis, potentially opening new avenues for understanding the underlying biology. If oxidative damage is confirmed as a mechanism in ME/CFS, it could lead to therapeutic strategies targeting antioxidant pathways or iron/copper metabolism.
This study does not establish that oxidative stress causes ME/CFS—only that it is associated with the condition. The cross-sectional design cannot determine whether oxidative damage is a primary driver of disease or a secondary consequence. The findings are also limited to a single snapshot in time and may not reflect all ME/CFS patients.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Manuel y Keenoy, B, Moorkens, G, Vertommen, J, & De Leeuw, I (2001). Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome.. Life sciences. https://doi.org/10.1016/s0024-3205(01)01001-3
BibTeX
@article{mecfsatlas-manuel-y-keenoy-2001-antioxidant-status,
author = {Manuel y Keenoy, B and Moorkens, G and Vertommen, J and De Leeuw, I},
title = {Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome.},
journal = {Life sciences},
year = {2001},
doi = {10.1016/s0024-3205(01)01001-3},
note = {PubMed: 11388705},
url = {https://www.mecfsatlas.com/evidence/manuel-y-keenoy-2001-antioxidant-status},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/manuel-y-keenoy-2001-antioxidant-status
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