Manysheva, Ksenia, Sherman, Mikhail, Zhukova, Natalia et al. · Psychiatria Danubina · 2022
This report describes one case of a 25-year-old woman who developed ME/CFS symptoms about 10 days after receiving the Sputnik V COVID-19 vaccine. She experienced severe fatigue, muscle pain, and difficulty moving. This is the first documented case linking ME/CFS to this particular vaccine, though it remains unclear whether the vaccine caused the condition or if it occurred by coincidence.
Post-viral and post-vaccination complications are important areas of investigation for ME/CFS, as understanding potential triggers may help identify underlying disease mechanisms and inform patient care strategies. This report contributes to the evolving discussion about adverse events following vaccines and calls attention to the need for systematic surveillance of ME/CFS development in vaccinated populations.
This single case report does not prove that Sputnik V vaccine causes ME/CFS. Temporal association does not establish causation, and without population-level data, comparative analysis, or mechanistic studies, it cannot rule out coincidental timing or other triggering factors. Systematic case reports and epidemiological studies would be needed to determine if ME/CFS occurs at higher rates in vaccinated versus unvaccinated populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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