Maoz, Daniel, Shoenfeld, Yehuda · Harefuah · 2006
ME/CFS is a serious illness that causes extreme tiredness and other symptoms that interfere with daily life. Doctors often fail to diagnose it correctly, and we still don't fully understand what causes it. This review suggests that ME/CFS likely results from multiple different factors working together, and that two treatments—cognitive behavioral therapy and graded exercise therapy—might help some patients.
This review underscores the critical gap between disease severity and clinical recognition—low diagnostic accuracy contributes to patients remaining undiagnosed and untreated. By framing ME/CFS as multifactorial and legitimate, the authors advocate for greater medical acceptance and awareness, which may improve patient outcomes and research funding.
This editorial review does not provide original experimental data, controlled trials, or mechanistic evidence for any proposed etiology. It does not establish causation for any suspected etiological factors, only notes their possible involvement. The endorsement of CBT and GET as potentially effective is based on literature review without presenting specific efficacy data or patient outcome metrics.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Maoz, Daniel & Shoenfeld, Yehuda (2006). [Chronic fatigue syndrome].. Harefuah. https://pubmed.ncbi.nlm.nih.gov/16642629/
BibTeX
@article{mecfsatlas-maoz-2006-chronic-fatigue,
author = {Maoz, Daniel and Shoenfeld, Yehuda},
title = {[Chronic fatigue syndrome].},
journal = {Harefuah},
year = {2006},
note = {PubMed: 16642629},
url = {https://www.mecfsatlas.com/evidence/maoz-2006-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/maoz-2006-chronic-fatigue
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