Maresca, Tomás, Covini, Elvira, Mato, Andrea Márquez López · Vertex (Buenos Aires, Argentina) · 2013
This review article explains Central Sensitivity Syndrome (CSS), a condition where the nervous system becomes overly sensitive to pain and other stimuli, and how it relates to ME/CFS and fibromyalgia. The authors describe how CSS differs from depression, even though people with CSS often experience depression as well, by comparing how the body's stress hormones, sleep patterns, and immune systems function differently in each condition.
This study helps clarify why ME/CFS and fibromyalgia patients often receive misdiagnoses of depression and why standard antidepressant treatments may be ineffective, potentially leading to better recognition and more appropriate medical management of these conditions.
This review does not present original experimental data or clinical trials, so it does not prove causation or establish new biomarkers. It synthesizes existing literature and does not validate a specific diagnostic test or treatment for CSS or ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Maresca, Tomás, Covini, Elvira, & Mato, Andrea Márquez López (2013). [Conditions, controversies and contradictions between Central Sensitivity Syndrome and Depressive Disorders].. Vertex (Buenos Aires, Argentina). https://pubmed.ncbi.nlm.nih.gov/24312923/
BibTeX
@article{mecfsatlas-maresca-2013-conditions-controversies,
author = {Maresca, Tomás and Covini, Elvira and Mato, Andrea Márquez López},
title = {[Conditions, controversies and contradictions between Central Sensitivity Syndrome and Depressive Disorders].},
journal = {Vertex (Buenos Aires, Argentina)},
year = {2013},
note = {PubMed: 24312923},
url = {https://www.mecfsatlas.com/evidence/maresca-2013-conditions-controversies},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/maresca-2013-conditions-controversies
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