Masson, Jean-Daniel, Badran, Ghidaa, Gherardi, Romain K et al. · Toxics · 2024 · DOI
This study examined immune cells from people with macrophagic myofasciitis (MMF), a condition involving long-term inflammation from vaccine aluminum adjuvants lodged in muscle tissue. Researchers found that these immune cells behave abnormally when exposed to aluminum adjuvants: they produce more pain-causing molecules, show signs of energy exhaustion, and struggle to respond to their normal workload. These findings suggest a possible mechanism for why MMF patients develop severe fatigue and widespread muscle pain similar to ME/CFS.
This research provides mechanistic insight into how vaccine aluminum adjuvants might trigger chronic fatigue and pain symptoms resembling ME/CFS through cellular dysfunction and mitochondrial energy depletion. Understanding these pathways could inform diagnosis, patient management, and development of targeted treatments for ME/CFS, particularly in vaccine-associated cases. The findings validate patient experiences of debilitating fatigue as rooted in identifiable cellular and metabolic abnormalities.
This in vitro study does not prove that aluminum adjuvants cause ME/CFS in the general population or establish causation in individual patients—it demonstrates mechanistic plausibility in a specific patient subgroup. The study cannot determine whether the observed cellular abnormalities are primary causes or secondary consequences of chronic immune activation. It also does not address whether these mechanisms apply to ME/CFS cases with other etiologies.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Masson, Jean-Daniel, Badran, Ghidaa, Gherardi, Romain K, Authier, François-Jérôme, & Crépeaux, Guillemette (2024). Widespread Myalgia and Chronic Fatigue: Phagocytes from Macrophagic Myofasciitis Patients Exposed to Aluminum Oxyhydroxide-Adjuvanted Vaccine Exhibit Specific Inflammatory, Autophagic, and Mitochondrial Responses.. Toxics. https://doi.org/10.3390/toxics12070491
BibTeX
@article{mecfsatlas-masson-2024-widespread-myalgia,
author = {Masson, Jean-Daniel and Badran, Ghidaa and Gherardi, Romain K and Authier, François-Jérôme and Crépeaux, Guillemette},
title = {Widespread Myalgia and Chronic Fatigue: Phagocytes from Macrophagic Myofasciitis Patients Exposed to Aluminum Oxyhydroxide-Adjuvanted Vaccine Exhibit Specific Inflammatory, Autophagic, and Mitochondrial Responses.},
journal = {Toxics},
year = {2024},
doi = {10.3390/toxics12070491},
note = {PubMed: 39058143},
url = {https://www.mecfsatlas.com/evidence/masson-2024-widespread-myalgia},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/masson-2024-widespread-myalgia
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