Miao, Xiaoyao, Li, Shuo, Xiao, Bingkun et al. · Biomedical chromatography : BMC · 2022 · DOI
Researchers tested whether a traditional Chinese medicine formula called Danggui Buxue Tang (DBT) could help rats with chronic fatigue syndrome caused by stress and food restriction. After 4 weeks of treatment, rats given DBT showed better energy levels, reduced fatigue markers in their blood, and improved physical performance compared to untreated rats with CFS.
This study provides mechanistic insight into how a traditional remedy may alleviate CFS symptoms by identifying specific metabolic pathways and chemical imbalances involved in the disease. Understanding these pathways could help researchers develop new treatments and validate metabolomic biomarkers for ME/CFS diagnosis and monitoring in humans.
This rat study does not prove that DBT will be effective or safe in humans with ME/CFS. Animal models of CFS induced by acute stress and food restriction may not capture the complexity of human ME/CFS etiology. The findings show association between metabolic changes and symptom improvement but do not definitively establish causation for all identified pathways.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Miao, Xiaoyao, Li, Shuo, Xiao, Bingkun, Yang, Jianyun, & Huang, Rongqing (2022). Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome.. Biomedical chromatography : BMC. https://doi.org/10.1002/bmc.5379
BibTeX
@article{mecfsatlas-miao-2022-metabolomics-study,
author = {Miao, Xiaoyao and Li, Shuo and Xiao, Bingkun and Yang, Jianyun and Huang, Rongqing},
title = {Metabolomics study of the effect of Danggui Buxue Tang on rats with chronic fatigue syndrome.},
journal = {Biomedical chromatography : BMC},
year = {2022},
doi = {10.1002/bmc.5379},
note = {PubMed: 35373377},
url = {https://www.mecfsatlas.com/evidence/miao-2022-metabolomics-study},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/miao-2022-metabolomics-study
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