Moldofsky, H, Saskin, P, Lue, F A · The Journal of rheumatology · 1988
This study looked at sleep patterns in people with fibromyalgia (a condition causing widespread pain and fatigue) who developed the condition after a fever, compared to people with fibromyalgia without a clear trigger and healthy volunteers. All fibromyalgia patients showed abnormal brain wave patterns during sleep that prevented their sleep from being truly restful, and they experienced similar muscle pain and tender points. This suggests that post-illness fibromyalgia shares the same sleep problems as other forms of fibromyalgia.
This early study is significant because it demonstrates that post-viral fibromyalgia and post-febrile fibrositis share the same sleep abnormality (alpha-EEG intrusion), suggesting a common biological mechanism regardless of trigger. For ME/CFS patients, this supports the connection between post-infection fatigue syndromes and sleep dysfunction, validating the overlap between these conditions.
This study does not prove that fever causes fibromyalgia, only that some patients attribute symptom onset to fever. It does not establish causation or identify what biological mechanism links febrile illness to sleep abnormalities. The small sample size means findings may not apply broadly to all post-infectious conditions or ME/CFS.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Moldofsky, H, Saskin, P, & Lue, F A (1988). Sleep and symptoms in fibrositis syndrome after a febrile illness.. The Journal of rheumatology. https://pubmed.ncbi.nlm.nih.gov/3236304/
BibTeX
@article{mecfsatlas-moldofsky-1988-sleep-symptoms,
author = {Moldofsky, H and Saskin, P and Lue, F A},
title = {Sleep and symptoms in fibrositis syndrome after a febrile illness.},
journal = {The Journal of rheumatology},
year = {1988},
note = {PubMed: 3236304},
url = {https://www.mecfsatlas.com/evidence/moldofsky-1988-sleep-symptoms},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/moldofsky-1988-sleep-symptoms
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