Nakane, Shunya, Koike, Haruki, Hayashi, Tomohiro et al. · International journal of molecular sciences · 2024 · DOI
This review describes autoimmune autonomic ganglionopathy (AAG), a rare condition where the immune system attacks nerve cells that control automatic body functions like heart rate and blood pressure. The authors explain how doctors can diagnose AAG and how it differs from other similar conditions, including ME/CFS and long COVID, which can have overlapping symptoms.
This review is important for ME/CFS patients and researchers because ME/CFS shares overlapping symptoms with AAG and other autoimmune neuropathies, yet may have distinct underlying mechanisms. Clarifying the diagnostic criteria and clinical features that distinguish AAG from ME/CFS can help ensure accurate diagnosis and appropriate treatment, preventing misclassification and enabling better clinical management.
This review does not establish that ME/CFS is caused by autoimmune mechanisms or gAChR autoantibodies, nor does it prove that patients with ME/CFS have AAG. The overlap in symptoms does not imply shared etiology; the authors note that differential diagnosis can be challenging but does not provide evidence that ME/CFS patients commonly have undiagnosed AAG.
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Primary citation
Nakane, Shunya, Koike, Haruki, Hayashi, Tomohiro, & Nakatsuji, Yuji (2024). Autoimmune Autonomic Neuropathy: From Pathogenesis to Diagnosis.. International journal of molecular sciences. https://doi.org/10.3390/ijms25042296
BibTeX
@article{mecfsatlas-nakane-2024-autoimmune-autonomic,
author = {Nakane, Shunya and Koike, Haruki and Hayashi, Tomohiro and Nakatsuji, Yuji},
title = {Autoimmune Autonomic Neuropathy: From Pathogenesis to Diagnosis.},
journal = {International journal of molecular sciences},
year = {2024},
doi = {10.3390/ijms25042296},
note = {PubMed: 38396973},
url = {https://www.mecfsatlas.com/evidence/nakane-2024-autoimmune-autonomic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/nakane-2024-autoimmune-autonomic
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