Nakaya, T, Kuratsune, H, Kitani, T et al. · Nihon rinsho. Japanese journal of clinical medicine · 1997
Researchers tested whether a virus called Borna disease virus (BDV) might be connected to ME/CFS. They found that some patients with ME/CFS had signs of BDV infection, and the virus was also detected in one family where multiple members had ME/CFS. While these findings suggest BDV could play a role, the study shows it's likely not the sole cause of ME/CFS.
Understanding potential viral triggers of ME/CFS is crucial for developing targeted diagnostic and therapeutic approaches. If viruses like BDV contribute to ME/CFS pathogenesis, this could explain disease heterogeneity and guide antiviral research strategies. Identifying biomarkers of viral infection may help stratify patient populations for better treatment outcomes.
This study does not prove that BDV causes ME/CFS, nor does it establish the direction of causality (infection could be a consequence rather than cause of immune dysfunction). The lack of a healthy control group limits our ability to determine whether BDV prevalence in CFS patients differs significantly from the general population. The study cannot explain why some infected individuals develop CFS while others do not.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Nakaya, T, Kuratsune, H, Kitani, T, & Ikuta, K (1997). [Demonstration on Borna disease virus in patients with chronic fatigue syndrome].. Nihon rinsho. Japanese journal of clinical medicine. https://pubmed.ncbi.nlm.nih.gov/9396313/
BibTeX
@article{mecfsatlas-nakaya-1997-demonstration-borna,
author = {Nakaya, T and Kuratsune, H and Kitani, T and Ikuta, K},
title = {[Demonstration on Borna disease virus in patients with chronic fatigue syndrome].},
journal = {Nihon rinsho. Japanese journal of clinical medicine},
year = {1997},
note = {PubMed: 9396313},
url = {https://www.mecfsatlas.com/evidence/nakaya-1997-demonstration-borna},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/nakaya-1997-demonstration-borna
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