Nikitina, M A, Bragina, E Yu, Ivanova, S A et al. · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2024 · DOI
This study looked at severe tiredness (chronic fatigue syndrome) in people with Parkinson's disease. Researchers found that about two-thirds of Parkinson's patients experience this kind of fatigue, and it tends to occur alongside other symptoms like mood problems, memory difficulties, and pain. Blood tests showed that people with this fatigue had higher levels of inflammation markers, suggesting that inflammation may play a role in causing the tiredness.
This study provides evidence that chronic fatigue in neurodegenerative disease involves inflammatory mechanisms—findings that parallel immunological hypotheses in ME/CFS. Understanding how inflammation correlates with fatigue severity across different neurological conditions may help identify shared pathways and guide therapeutic development for fatigue in both ME/CFS and Parkinson's disease.
This study does not establish causation—elevated inflammatory markers are associated with fatigue severity but do not prove inflammation causes the fatigue. The findings are specific to Parkinson's disease patients and may not directly apply to primary ME/CFS. Additionally, the two examined genetic polymorphisms were not associated with CFS development or protein levels, so they do not explain the fatigue-inflammation relationship.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Nikitina, M A, Bragina, E Yu, Ivanova, S A, Boyko, A S, Levchuk, L A, Nazarenko, M S, et al. (2024). [Association of inflammation and chronic fatigue syndrome in patients with Parkinson's disease].. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. https://doi.org/10.17116/jnevro202412409179
BibTeX
@article{mecfsatlas-nikitina-2024-association-inflammation,
author = {Nikitina, M A and Bragina, E Yu and Ivanova, S A and Boyko, A S and Levchuk, L A and Nazarenko, M S and Alifirova, V M},
title = {[Association of inflammation and chronic fatigue syndrome in patients with Parkinson's disease].},
journal = {Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova},
year = {2024},
doi = {10.17116/jnevro202412409179},
note = {PubMed: 39435781},
url = {https://www.mecfsatlas.com/evidence/nikitina-2024-association-inflammation},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/nikitina-2024-association-inflammation
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