Ogawa, R, Toyama, S, Matsumoto, H · Nihon rinsho. Japanese journal of clinical medicine · 1992
This study looked at 134 ME/CFS patients seen at one hospital in Japan and found that many had immune system abnormalities, including weakened natural killer cells and reactions to common substances like dust and pollen. Researchers also discovered some patients had low levels of certain fatty acids in their blood. When treated with a traditional Chinese herbal medicine called Ren-Shen-Yang-Rong-Tang, about 73% of patients were able to return to work or school.
This study highlights immune system abnormalities—particularly natural killer cell dysfunction and fatty acid deficiencies—that may contribute to ME/CFS pathology, suggesting that immune dysregulation is a relevant therapeutic target. The relatively high functional recovery rate (73%) provides preliminary evidence that herbal medicine approaches warrant further investigation, though rigorous controlled trials are needed.
This study does not prove that Ren-Shen-Yang-Rong-Tang is an effective ME/CFS treatment, as there was no control group, blinding, or standardized outcome measures. It also does not establish causation between the observed immune abnormalities and ME/CFS symptoms, nor does it determine whether immune findings are characteristic of all ME/CFS patients or represent a specific subgroup. Recovery to work/school status does not necessarily indicate full symptom resolution or sustained improvement.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Ogawa, R, Toyama, S, & Matsumoto, H (1992). [Chronic fatigue syndrome--cases in the Kanebo Memorial Hospital].. Nihon rinsho. Japanese journal of clinical medicine. https://pubmed.ncbi.nlm.nih.gov/1337561/
BibTeX
@article{mecfsatlas-ogawa-1992-chronic-fatigue,
author = {Ogawa, R and Toyama, S and Matsumoto, H},
title = {[Chronic fatigue syndrome--cases in the Kanebo Memorial Hospital].},
journal = {Nihon rinsho. Japanese journal of clinical medicine},
year = {1992},
note = {PubMed: 1337561},
url = {https://www.mecfsatlas.com/evidence/ogawa-1992-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/ogawa-1992-chronic-fatigue
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