Petrides, George, Zalewski, Pawel, McCulloch, David et al. · Fatigue : biomedicine, health & behavior · 2017 · DOI
This study looked at how the nervous system controls the heart in people with ME/CFS, focusing on a specific part called the sympathetic nervous system. Researchers used specialized imaging to examine nerve connections in the heart and compared them to problems with autonomic function (the automatic nervous system that controls heart rate and blood pressure). The findings suggest that differences in heart nerve connections may be related to why some ME/CFS patients experience autonomic symptoms like dizziness and heart rate changes.
Autonomic dysfunction is a major and disabling feature of ME/CFS affecting many patients' quality of life. This study provides potential mechanistic evidence that observable changes in cardiac nerve structure or function may underlie autonomic symptoms, which could eventually guide development of targeted treatments and improve understanding of disease pathophysiology.
This pilot study does not establish causation or explain why sympathetic innervation changes occur in ME/CFS. The small sample size and lack of control group limits generalizability, and the findings may not apply to all ME/CFS patients or those without autonomic symptoms. Correlation between imaging findings and autonomic dysfunction does not prove these changes cause the symptoms.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Petrides, George, Zalewski, Pawel, McCulloch, David, Maclachlan, Laura, Finkelmeyer, Andreas, Hodgson, Tim, et al. (2017). Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.. Fatigue : biomedicine, health & behavior. https://doi.org/10.1080/21641846.2017.1322235
BibTeX
@article{mecfsatlas-petrides-2017-cardiac-sympathetic,
author = {Petrides, George and Zalewski, Pawel and McCulloch, David and Maclachlan, Laura and Finkelmeyer, Andreas and Hodgson, Tim and Blamire, Andrew and Newton, Julia L},
title = {Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome - a pilot study.},
journal = {Fatigue : biomedicine, health & behavior},
year = {2017},
doi = {10.1080/21641846.2017.1322235},
note = {PubMed: 29780660},
url = {https://www.mecfsatlas.com/evidence/petrides-2017-cardiac-sympathetic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/petrides-2017-cardiac-sympathetic
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