Pieczenik, Steve R, Neustadt, John · Experimental and molecular pathology · 2007 · DOI
This article explains that many different diseases—including chronic fatigue syndrome—may share a common problem: damage to mitochondria, the energy-producing parts of our cells. When mitochondria don't work properly, they produce harmful molecules called reactive oxygen species that can further damage cells. The authors suggest that antioxidant treatments and specific urine tests might help doctors treat these conditions more effectively.
This study is significant because it positions ME/CFS within a broader framework of mitochondrial disease, potentially opening new research directions and treatment approaches. For ME/CFS patients, understanding a possible mitochondrial basis for the disease could explain symptom patterns like post-exertional malaise and guide development of targeted therapies currently lacking.
This review does not prove that mitochondrial dysfunction causes ME/CFS, only that it may be involved in the pathophysiology. It does not present new clinical trial data showing that antioxidant therapies actually work in ME/CFS patients, nor does it validate urinary organic acid testing as a diagnostic tool specifically for this population. The article does not establish causation or demonstrate that addressing mitochondrial function will effectively treat the disease.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Pieczenik, Steve R & Neustadt, John (2007). Mitochondrial dysfunction and molecular pathways of disease.. Experimental and molecular pathology. https://doi.org/10.1016/j.yexmp.2006.09.008
BibTeX
@article{mecfsatlas-pieczenik-2007-mitochondrial-dysfunction,
author = {Pieczenik, Steve R and Neustadt, John},
title = {Mitochondrial dysfunction and molecular pathways of disease.},
journal = {Experimental and molecular pathology},
year = {2007},
doi = {10.1016/j.yexmp.2006.09.008},
note = {PubMed: 17239370},
url = {https://www.mecfsatlas.com/evidence/pieczenik-2007-mitochondrial-dysfunction},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/pieczenik-2007-mitochondrial-dysfunction
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