Rangel, Luiza, Garralda, M Elena, Jeffs, Jim et al. · Journal of the American Academy of Child and Adolescent Psychiatry · 2005 · DOI
This study looked at families of children with ME/CFS and compared them to families of children with juvenile rheumatoid arthritis (JRA, an autoimmune joint disease) and emotional disorders like anxiety or depression. Researchers found that parents of children with ME/CFS were more likely to have ME/CFS-like symptoms themselves, experience greater emotional stress, and report their child's illness as more burdensome to family life compared to parents of children with JRA.
Understanding family patterns in ME/CFS is important because it highlights that the illness impacts not just the affected child but the entire family system. This study provides evidence that ME/CFS has distinctive family characteristics compared to other chronic pediatric conditions, which may inform family-centered clinical approaches and help validate patients' experiences.
This study does not prove whether parental ME/CFS-like illness causes childhood CFS, results from caring for a child with CFS, or reflects shared genetic or environmental factors. The cross-sectional design captures associations at a single time point and cannot establish temporal relationships or direction of causality. It also does not establish that family factors play a causal role in CFS etiology or maintenance.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Rangel, Luiza, Garralda, M Elena, Jeffs, Jim, & Rose, Gillian (2005). Family health and characteristics in chronic fatigue syndrome, juvenile rheumatoid arthritis, and emotional disorders of childhood.. Journal of the American Academy of Child and Adolescent Psychiatry. https://doi.org/10.1097/00004583-200502000-00007
BibTeX
@article{mecfsatlas-rangel-2005-family-health,
author = {Rangel, Luiza and Garralda, M Elena and Jeffs, Jim and Rose, Gillian},
title = {Family health and characteristics in chronic fatigue syndrome, juvenile rheumatoid arthritis, and emotional disorders of childhood.},
journal = {Journal of the American Academy of Child and Adolescent Psychiatry},
year = {2005},
doi = {10.1097/00004583-200502000-00007},
note = {PubMed: 15689728},
url = {https://www.mecfsatlas.com/evidence/rangel-2005-family-health},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/rangel-2005-family-health
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