Reid, S, Chalder, T, Cleare, A et al. · BMJ (Clinical research ed.) · 2000 · DOI
This was a systematic review that brought together existing research about chronic fatigue syndrome (ME/CFS) to understand what was known at the time. The researchers looked at multiple studies to summarize the current evidence about the condition. This type of overview helps doctors and patients understand the state of knowledge about ME/CFS.
Systematic reviews provide crucial summaries of the evidence base and help establish clinical consensus. For ME/CFS patients, this review represented an important effort by mainstream medical researchers to comprehensively evaluate what was known about their condition at the time. This work contributed to raising the profile of ME/CFS in the medical literature and helped guide clinical approaches.
This systematic review synthesizes existing evidence but does not itself generate new experimental data or identify biological mechanisms of ME/CFS. It cannot prove causation for any particular risk factors or treatments—it can only summarize what other studies have found. The conclusions are limited by the quantity and quality of research available up to 2000, which may not reflect current understanding.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Reid, S, Chalder, T, Cleare, A, Hotopf, M, & Wessely, S (2000). Chronic fatigue syndrome.. BMJ (Clinical research ed.). https://doi.org/10.1136/bmj.320.7230.292
BibTeX
@article{mecfsatlas-reid-2000-chronic-fatigue,
author = {Reid, S and Chalder, T and Cleare, A and Hotopf, M and Wessely, S},
title = {Chronic fatigue syndrome.},
journal = {BMJ (Clinical research ed.)},
year = {2000},
doi = {10.1136/bmj.320.7230.292},
note = {PubMed: 10650029},
url = {https://www.mecfsatlas.com/evidence/reid-2000-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/reid-2000-chronic-fatigue
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