Robotti, Elisa, Quasso, Fabio, Manfredi, Marcello et al. · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020 · DOI
This study looked at one patient with ME/CFS symptoms who may have had heavy metal poisoning. The doctors gave the patient a chelation therapy treatment (a medicine designed to bind to and remove heavy metals from the body) every two weeks for 17 months, and measured how much metal came out in the urine. The study found that most heavy metals were eliminated in the first 24 hours after treatment, but the effect wore off quickly—suggesting more frequent treatments might work better.
Some ME/CFS patients and practitioners have hypothesized that heavy metal accumulation may contribute to ME/CFS symptoms. This study provides a methodology for dynamically monitoring metal excretion during chelation therapy and raises questions about optimal treatment frequency. However, the findings remain preliminary and are based on a single uncontrolled case.
This case study does not prove that heavy metal intoxication causes or contributes to ME/CFS; the association between metals and the patient's symptoms is only suspected, not established. It does not compare chelation therapy to placebo or standard care, nor does it measure whether the treatment improved the patient's ME/CFS symptoms or functional outcomes. The findings apply only to one individual and cannot be generalized to other ME/CFS patients.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Robotti, Elisa, Quasso, Fabio, Manfredi, Marcello, Gosetti, Fabio, Mazzucco, Eleonora, Isidoro, Ciro, et al. (2020). Determination by ICP-MS and multivariate data analysis of elemental urine excretion profile during the EDTA chelation therapy: A case study.. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). https://doi.org/10.1016/j.jtemb.2020.126608
BibTeX
@article{mecfsatlas-robotti-2020-determination-icp,
author = {Robotti, Elisa and Quasso, Fabio and Manfredi, Marcello and Gosetti, Fabio and Mazzucco, Eleonora and Isidoro, Ciro and Marengo, Emilio},
title = {Determination by ICP-MS and multivariate data analysis of elemental urine excretion profile during the EDTA chelation therapy: A case study.},
journal = {Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)},
year = {2020},
doi = {10.1016/j.jtemb.2020.126608},
note = {PubMed: 32853885},
url = {https://www.mecfsatlas.com/evidence/robotti-2020-determination-icp},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/robotti-2020-determination-icp
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