Sato, Eiji, Yoshikawa, Rokusuke, Miyazawa, Takayuki · The Journal of veterinary medical science · 2012 · DOI
Researchers developed two new laboratory tests to detect and measure XMRV, a virus that was discovered in some people with chronic fatigue syndrome and prostate cancer. They compared a newer, simpler test called a 'focus assay' with an older test called a 'LacZ marker rescue assay' and found that both tests detected the virus equally well, though the newer test was easier to use.
Developing sensitive and practical laboratory methods to detect XMRV is essential for understanding whether this virus plays a role in ME/CFS. Better detection tools enable researchers to clarify the prevalence of XMRV in patient populations and investigate its biological significance, which is necessary to resolve the ongoing scientific controversy about XMRV's association with the disease.
This study does not prove that XMRV causes ME/CFS or is directly associated with the disease in patients. It is purely a methodological comparison of laboratory detection techniques and does not include patient samples or clinical data. The study cannot establish whether XMRV is truly present in CFS patients or what role it may play in disease pathogenesis.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Sato, Eiji, Yoshikawa, Rokusuke, & Miyazawa, Takayuki (2012). Comparison of two quantitative assays for xenotropic murine leukemia virus-related virus.. The Journal of veterinary medical science. https://doi.org/10.1292/jvms.11-0362
BibTeX
@article{mecfsatlas-sato-2012-comparison-two,
author = {Sato, Eiji and Yoshikawa, Rokusuke and Miyazawa, Takayuki},
title = {Comparison of two quantitative assays for xenotropic murine leukemia virus-related virus.},
journal = {The Journal of veterinary medical science},
year = {2012},
doi = {10.1292/jvms.11-0362},
note = {PubMed: 21959892},
url = {https://www.mecfsatlas.com/evidence/sato-2012-comparison-two},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/sato-2012-comparison-two
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