Shreevathsa, M, Ravishankar, B, Dwivedi, Rambabu · Ayu · 2013 · DOI
Researchers tested an Ayurvedic herbal mixture called Mamsyadi Kwatha to see if it could help with depression and fatigue-like symptoms in mice. The mixture contains three plant ingredients and showed some ability to reduce signs of depression and fatigue in animal tests, suggesting it might have antidepressant properties.
This study is relevant to ME/CFS research because it explicitly tested a botanical formulation in a 'Chronic Fatigue Syndrome' animal model, potentially offering insight into traditional medicine approaches to fatigue and depression comorbidity. For ME/CFS patients experiencing depression or fatigue, understanding mechanistic pathways of herbal interventions may inform future clinical investigation.
This animal study does not prove that Mamsyadi Kwatha is safe or effective in humans with ME/CFS or depression. The 'CFS test' in mice may not accurately model human ME/CFS pathophysiology. Results in rodent behavioral models do not establish that symptom improvement would occur in patients or clarify which ingredients are active.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Shreevathsa, M, Ravishankar, B, & Dwivedi, Rambabu (2013). Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation.. Ayu. https://doi.org/10.4103/0974-8520.115448
BibTeX
@article{mecfsatlas-shreevathsa-2013-anti-depressant,
author = {Shreevathsa, M and Ravishankar, B and Dwivedi, Rambabu},
title = {Anti depressant activity of Mamsyadi Kwatha: An Ayurvedic compound formulation.},
journal = {Ayu},
year = {2013},
doi = {10.4103/0974-8520.115448},
note = {PubMed: 24049416},
url = {https://www.mecfsatlas.com/evidence/shreevathsa-2013-anti-depressant},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/shreevathsa-2013-anti-depressant
Contribute
Private, reviewed by a human. Not a public comment thread.