Signorile, Pietro G, Cassano, Maria, Viceconte, Rosa et al. · In vivo (Athens, Greece) · 2022 · DOI
This study looked at health records from over 4,000 women with endometriosis (a painful condition where tissue grows outside the uterus) to understand which symptoms are most common. The researchers found that chronic fatigue, painful intercourse, and bowel problems are major symptoms of endometriosis, and interestingly, symptoms tend to peak in women aged 25-44 years before declining. The study suggests that having children may help reduce fatigue in women with endometriosis.
While this study focuses on endometriosis rather than ME/CFS, it is relevant because chronic fatigue was identified as a major symptom in a large patient population, and understanding how fatigue presents alongside other gynecological conditions may inform differential diagnosis in ME/CFS patients. The symptom overlap (fatigue, pain, functional impairment) highlights the importance of distinguishing between conditions and understanding how chronic conditions with complex symptomatology affect diagnosis and patient outcomes.
This study does not establish causation—only associations between endometriosis and various symptoms. It does not prove that chronic fatigue in endometriosis patients is the same as ME/CFS, nor does it clarify whether fatigue is directly caused by endometriosis or is a separate comorbid condition. As a retrospective analysis relying on archived data, it cannot establish diagnostic accuracy or validate the presence of ME/CFS in this population.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Signorile, Pietro G, Cassano, Maria, Viceconte, Rosa, Marcattilj, Valentina, & Baldi, Alfonso (2022). Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms.. In vivo (Athens, Greece). https://doi.org/10.21873/invivo.12776
BibTeX
@article{mecfsatlas-signorile-2022-endometriosis-retrospective,
author = {Signorile, Pietro G and Cassano, Maria and Viceconte, Rosa and Marcattilj, Valentina and Baldi, Alfonso},
title = {Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, With Focus on Symptoms.},
journal = {In vivo (Athens, Greece)},
year = {2022},
doi = {10.21873/invivo.12776},
note = {PubMed: 35241545},
url = {https://www.mecfsatlas.com/evidence/signorile-2022-endometriosis-retrospective},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/signorile-2022-endometriosis-retrospective
Contribute
Private, reviewed by a human. Not a public comment thread.