Sánchez Rodríguez, A, González Maroño, C, Sánchez Ledesma, M · Revista clinica espanola · 2005 · DOI
This review examines how ME/CFS is defined and understood in clinical practice. The authors discuss the challenges doctors face in recognizing and diagnosing this condition, since it affects different people in different ways. The study highlights why having clear, consistent definitions is essential for helping patients get proper care and advancing research.
Clear, consistent definitions of ME/CFS are crucial for ensuring patients receive accurate diagnoses and appropriate care. When doctors use different definitions, research findings become harder to compare and patients may receive inconsistent or delayed diagnoses. This review contributes to ongoing efforts to establish standardized criteria that benefit both clinical practice and research.
This review does not provide new data on disease mechanisms, prevalence, or treatment outcomes. It cannot establish causation or identify biological markers for ME/CFS, as it synthesizes existing literature rather than conducting original experiments or clinical observations. The conclusions depend on the quality and scope of the sources reviewed.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Sánchez Rodríguez, A, González Maroño, C, & Sánchez Ledesma, M (2005). [Chronic fatigue syndrome: a syndrome in search of definition].. Revista clinica espanola. https://doi.org/10.1157/13072499
BibTeX
@article{mecfsatlas-snchez-rodrguez-2005-chronic-fatigue,
author = {Sánchez Rodríguez, A and González Maroño, C and Sánchez Ledesma, M},
title = {[Chronic fatigue syndrome: a syndrome in search of definition].},
journal = {Revista clinica espanola},
year = {2005},
doi = {10.1157/13072499},
note = {PubMed: 15766479},
url = {https://www.mecfsatlas.com/evidence/snchez-rodrguez-2005-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/snchez-rodrguez-2005-chronic-fatigue
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